A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC

Yu V. Patrushev; Yu S. Sotnikova; V. N. Sidel’nikov

doi:10.1134/S2070205119060248

A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC

Yu V. Patrushev, Yu S. Sotnikova, V. N. Sidel’nikov

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract: A monolithic chromatographic column for HPLC with a sorbent based on 1-vinyl-1,2,4-triazole has been prepared for the first time. It has been shown that, depending on the composition of the mobile phase (acetonitrile/water ratio), this column is able to operate in the modes of both reverse phase chromatography and hydrophilic chromatography. The dependences of the retention factor on the volume fraction of acetonitrile in the mobile phase have been studied for substances of acidic and basic nature. An example of the separation of the components of the pharmaceutical product Askofen-P on the prepared column has been provided.

Original language	English
Pages (from-to)	49-53
Number of pages	5
Journal	Protection of Metals and Physical Chemistry of Surfaces
Volume	56
Issue number	1
DOIs	https://doi.org/10.1134/S2070205119060248
Publication status	Published - Jan 2020

Keywords

1-vinyl-1,2,4-triazole
HPLC
hydrophilic interaction chromatography
monolithic columns
porous polymers
ROD COLUMNS
4-triazole
ACID
CAPILLARY COLUMNS
2
1-vinyl-1
POLYMER
SEPARATION
SELECTIVITY
INTERACTION CHROMATOGRAPHY

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10.1134/S2070205119060248

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title = "A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC",

abstract = "Abstract: A monolithic chromatographic column for HPLC with a sorbent based on 1-vinyl-1,2,4-triazole has been prepared for the first time. It has been shown that, depending on the composition of the mobile phase (acetonitrile/water ratio), this column is able to operate in the modes of both reverse phase chromatography and hydrophilic chromatography. The dependences of the retention factor on the volume fraction of acetonitrile in the mobile phase have been studied for substances of acidic and basic nature. An example of the separation of the components of the pharmaceutical product Askofen-P on the prepared column has been provided.",

keywords = "1-vinyl-1,2,4-triazole, HPLC, hydrophilic interaction chromatography, monolithic columns, porous polymers, ROD COLUMNS, 4-triazole, ACID, CAPILLARY COLUMNS, 2, 1-vinyl-1, POLYMER, SEPARATION, SELECTIVITY, INTERACTION CHROMATOGRAPHY",

author = "Patrushev, {Yu V.} and Sotnikova, {Yu S.} and Sidel{\textquoteright}nikov, {V. N.}",

year = "2020",

month = jan,

doi = "10.1134/S2070205119060248",

language = "English",

volume = "56",

pages = "49--53",

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T1 - A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC

AU - Patrushev, Yu V.

AU - Sotnikova, Yu S.

AU - Sidel’nikov, V. N.

PY - 2020/1

Y1 - 2020/1

N2 - Abstract: A monolithic chromatographic column for HPLC with a sorbent based on 1-vinyl-1,2,4-triazole has been prepared for the first time. It has been shown that, depending on the composition of the mobile phase (acetonitrile/water ratio), this column is able to operate in the modes of both reverse phase chromatography and hydrophilic chromatography. The dependences of the retention factor on the volume fraction of acetonitrile in the mobile phase have been studied for substances of acidic and basic nature. An example of the separation of the components of the pharmaceutical product Askofen-P on the prepared column has been provided.

AB - Abstract: A monolithic chromatographic column for HPLC with a sorbent based on 1-vinyl-1,2,4-triazole has been prepared for the first time. It has been shown that, depending on the composition of the mobile phase (acetonitrile/water ratio), this column is able to operate in the modes of both reverse phase chromatography and hydrophilic chromatography. The dependences of the retention factor on the volume fraction of acetonitrile in the mobile phase have been studied for substances of acidic and basic nature. An example of the separation of the components of the pharmaceutical product Askofen-P on the prepared column has been provided.

KW - 1-vinyl-1,2,4-triazole

KW - HPLC

KW - hydrophilic interaction chromatography

KW - monolithic columns

KW - porous polymers

KW - ROD COLUMNS

KW - 4-triazole

KW - ACID

KW - CAPILLARY COLUMNS

KW - 2

KW - 1-vinyl-1

KW - POLYMER

KW - SEPARATION

KW - SELECTIVITY

KW - INTERACTION CHROMATOGRAPHY

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U2 - 10.1134/S2070205119060248

DO - 10.1134/S2070205119060248

M3 - Article

AN - SCOPUS:85083177067

VL - 56

SP - 49

EP - 53

JO - Protection of Metals and Physical Chemistry of Surfaces

JF - Protection of Metals and Physical Chemistry of Surfaces

SN - 2070-2051

IS - 1

ER -

A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC

Abstract

Keywords

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