A facile approach to hybrid compounds containing a tricyclic diterpenoid and fluorine-substituted heterocycles

M. A. Gromova, Yu V. Kharitonov, L. V. Politanskaya, E. V. Tretyakov, E. E. Shults

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

2,3-Butadienes have become valuable building blocks in the synthesis of various heterocyclic compounds. The Pd-catalyzed cross-coupling and cyclization reaction of N-(2,3-butadienyl)carboxamide of isopimaric acid with fluorine-substituted 2-iodophenols proceeds with the formation of optically active fluorinated benzofuran and benzopyrane derivatives of isopimaric acid. This transformation opens a potential route to the synthesis of hybrid compounds containing a tricyclic diterpenoid moiety and several fluorinated benzoannelated heterocycles.

Original languageEnglish
Article number109554
Number of pages8
JournalJournal of Fluorine Chemistry
Volume236
DOIs
Publication statusPublished - 1 Aug 2020

Keywords

  • 2Н-chromenes
  • Benzofurans
  • Cross-coupling-cyclization
  • Fluorinated heterocycles
  • Isopimaric acid
  • Terpenoid allene
  • BIOACTIVITY
  • ACID
  • PHARMACEUTICALS
  • CHROMENE
  • 2H-chromenes
  • BENZOFURANS
  • DERIVATIVES
  • EFFICIENT

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