A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity

Anna A. Krasilnikova, Anastasiya O. Solovieva, Anton A. Ivanov, Konstantin A. Brylev, Tatiana N. Pozmogova, Marina A. Gulyaeva, Olga G. Kurskaya, Alexander Y. Alekseev, Alexander M. Shestopalov, Lidiya V. Shestopalova, Alexander F. Poveshchenko, Olga A. Efremova, Yuri V. Mironov, Michael A. Shestopalov

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].

Original languageEnglish
Pages (from-to)554-560
Number of pages7
JournalToxicology Research
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • CELLS
  • CELLULAR INTERNALIZATION
  • CHRONIC INFLAMMATION
  • CYTOTOXICITY
  • DISEASES
  • ENCAPSULATION
  • GOLD NANOPARTICLES
  • LUMINESCENCE
  • RAY CONTRAST AGENT
  • SILICA NANOPARTICLES

Fingerprint Dive into the research topics of 'A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity'. Together they form a unique fingerprint.

Cite this