2-Imidazoline Nitroxide Derivatives of Cymantrene

Kseniya Maryunina, Gleb Letyagin, Galina Romanenko, Artem Bogomyakov, Vitaly Morozov, Sergey Tumanov, Sergey Veber, Matvey Fedin, Evgeniya Saverina, Mikhail Syroeshkin, Mikhail Egorov, Victor Ovcharenko

Research output: Contribution to journalArticlepeer-review

Abstract

The 2-imidazoline nitroxide derivatives of cymantrene-2-(η5-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (NNMn) and 2-(η5-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-1-oxyl (INMn) were synthesized. It was shown that NNMn and INMn exhibit a sufficiently high kinetic stability both in solids and in solutions under normal conditions. Their structural characteristics, magnetic properties and electrochemical behavior are close to Re(I) analogs. This opens the prospect of using paramagnetic cymantrenes as prototypes in the design of Re(I) half-sandwiched derivatives for theranostics, where therapy is combined with diagnostics by magnetic resonance imaging due to the contrast properties of nitroxide radicals.

Original languageEnglish
Article number7545
JournalMolecules (Basel, Switzerland)
Volume27
Issue number21
DOIs
Publication statusPublished - 3 Nov 2022

Keywords

  • cymantrene
  • manganeseorganic
  • nitroxide
  • paramagnets

OECD FOS+WOS

  • 3.01 BASIC MEDICAL RESEARCH
  • 1.04 CHEMICAL SCIENCES

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