Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins

N. A. Popova, V. P. Nikolin, V. I. Kaledin, I. A. Serova, E. A. Matyunina, M. A. Bakarev, E. L. Lushnikova, A. N. Vologodskii

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the effect of a new targeted drug Pefagtal that represents a conjugate in which the MS2 phage filled with a substance toxic to cells (thallium salts) is covalently linked to peptides containing the RGD motif. The antitumor and pronounced antimetastatic effects of Pefagtal were demonstrated on transplanted mouse tumors differing in histological type and status of metastasis: Krebs-2 ascites adenocarcinoma of the mammary gland, Lewis lung adenocarcinoma, hepatoma-29, and lung adenocarcinoma. It is assumed that the RGD motif mediates primary binding of the construct to αvβ3 and αvβ5 integrins that are predominantly overexpressed in the endothelial cells of tumor blood vessels and in tumor and metastatic cells.

Translated title of the contributionЭкспериментальное изучение противоопухолевой активности препарата "Пефагтал", адресованного к αvβ3-интегринам
Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume173
Issue number1
DOIs
Publication statusPublished - May 2022

Keywords

  • drug Pefagtal
  • metastases
  • mice tumors
  • targeted therapy
  • αvβ3 integrins
  • Adenocarcinoma of Lung
  • Integrin alphaVbeta3/metabolism
  • Oligopeptides/chemistry
  • Liver Neoplasms
  • Animals
  • Endothelial Cells/metabolism
  • Mice
  • Carcinoma, Hepatocellular

OECD FOS+WOS

  • 3.01.QA MEDICINE, RESEARCH & EXPERIMENTAL
  • 1.06 BIOLOGICAL SCIENCES

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