Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety

N. N. Dygalo; D. A. Lanshakov; N. P. Komysheva; U. S. Drozd; E. V. Shaburova; E. V. Sukhareva; G. T. Shishkina

doi:10.1134/S1607672920010056

Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety

N. N. Dygalo, D. A. Lanshakov, N. P. Komysheva, U. S. Drozd, E. V. Shaburova, E. V. Sukhareva, G. T. Shishkina

Research output: Contribution to journal › Article › peer-review

Abstract

Chemogenetic activation of glutamatergic neurons of the prefrontal cortex reduces the manifestations of psychoemotional anxiety during the juvenile period of ontogenesis. This result is the first evidence of feasibility of targeted chemogenetic control of neuronal activity during the early stages of brain development.

Translated title of the contribution	Хемогенетическая активация глутаматергических нейронов коры ювенильных крысят снижает тревожность
Original language	English
Article number	5
Pages (from-to)	16-18
Number of pages	3
Journal	Doklady Biochemistry and Biophysics
Volume	490
Issue number	1
DOIs	https://doi.org/10.1134/S1607672920010056
Publication status	Published - 1 Jan 2020

Keywords

anxiety
chemogenetics
glutamatergic neurons
juvenile period of ontogenesis
prefrontal cortex

OECD FOS+WOS

1.06.CQ BIOCHEMISTRY & MOLECULAR BIOLOGY

State classification of scientific and technological information

34 BIOLOGY

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10.1134/S1607672920010056

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title = "Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety",

abstract = "Chemogenetic activation of glutamatergic neurons of the prefrontal cortex reduces the manifestations of psychoemotional anxiety during the juvenile period of ontogenesis. This result is the first evidence of feasibility of targeted chemogenetic control of neuronal activity during the early stages of brain development.",

keywords = "anxiety, chemogenetics, glutamatergic neurons, juvenile period of ontogenesis, prefrontal cortex",

author = "Dygalo, {N. N.} and Lanshakov, {D. A.} and Komysheva, {N. P.} and Drozd, {U. S.} and Shaburova, {E. V.} and Sukhareva, {E. V.} and Shishkina, {G. T.}",

note = "This work was supported by the Russian Science Foundation (project no. 19-15-00093).",

year = "2020",

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doi = "10.1134/S1607672920010056",

language = "English",

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T1 - Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety

AU - Dygalo, N. N.

AU - Lanshakov, D. A.

AU - Komysheva, N. P.

AU - Drozd, U. S.

AU - Shaburova, E. V.

AU - Sukhareva, E. V.

AU - Shishkina, G. T.

N1 - This work was supported by the Russian Science Foundation (project no. 19-15-00093).

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Chemogenetic activation of glutamatergic neurons of the prefrontal cortex reduces the manifestations of psychoemotional anxiety during the juvenile period of ontogenesis. This result is the first evidence of feasibility of targeted chemogenetic control of neuronal activity during the early stages of brain development.

AB - Chemogenetic activation of glutamatergic neurons of the prefrontal cortex reduces the manifestations of psychoemotional anxiety during the juvenile period of ontogenesis. This result is the first evidence of feasibility of targeted chemogenetic control of neuronal activity during the early stages of brain development.

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KW - chemogenetics

KW - glutamatergic neurons

KW - juvenile period of ontogenesis

KW - prefrontal cortex

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Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety

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Keywords

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