In vitro photodynamic inactivation of Mycobacterium tuberculosis by methylene blue

D. Bredikhin, S. D. Nikonov, A. G. Cherednichenko, T. I. Petrenko, A. I. Korbut

Research output: Contribution to journalArticlepeer-review

Abstract

The objective: to investigate the anti-tuberculosis effect of laser photodynamic inactivation (PDI) of M. tuberculosis H37Rv in vitro by methylene blue (MB) in the minimum concentration (1 μg/ml) with laser radiation of 662 nm. Subjects and methods. A comparative analysis of the intensity of growth of Mycobacterium tuberculosis H37Rv after laser irradiation and laser FDI by MB with different doses of light energy was carried out. Results. Laser radiation with a wavelength of 662 nm was found to have an inhibitory effect on the growth of M. tuberculosis H37Rv. FDI of Mycobacterium tuberculosis was first registered in the presence of a minimum concentration of MB (1 µg/ml) which suppressed colony growth by 97 and 93% when they were processed by radiation with a wavelength of 662 nm with the lowest density of doses of light energy (46.9 and 93.75 J/cm2).

Translated title of the contributionФотодинамическая инактивация Mycobacterium tuberculosis метиленовым синим in vitro
Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalTuberculosis and Lung Diseases
Volume97
Issue number7
DOIs
Publication statusPublished - 1 Jan 2019

State classification of scientific and technological information

  • 76 MEDICINE AND HEALTH CARE

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