Фазовые портреты моделей двух генных сетей

Translated title of the contribution: Phase portraits of two gene networks models

Research output: Contribution to journalArticlepeer-review

Abstract

We construct mathematical models of functioning of two few-components gene networks which regulate circadian rhythmes in organisms by means of combinations of positive and negative feedbacks between components of these networks. Both models are represented in the form of non-linear dynamical systems of biochemical kinetics. It is shown that the phase portraits of both models contain exactly one equilibrium point each and in both cases for all values of parameters of these dynamical systems, eigenvalues of their linearization matrices at their equilibrium points are either negative or have negative real parts. Thus, these equilibrium points are stable. We construct their invariant neighborhoods and describe the behavior of trajectories of these systems. Biological interpretations of these results are given as well.

Translated title of the contributionPhase portraits of two gene networks models
Original languageRussian
Article number1
Pages (from-to)3-11
Number of pages9
JournalMathematical Notes of NEFU
Volume28
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • Equilibrium point
  • Gene networks models
  • Non-linear dynamical systems
  • Phase portrait
  • Stability
  • Vyshnegradskii criterion

OECD FOS+WOS

  • 1.02 COMPUTER AND INFORMATION SCIENCES
  • 1.01 MATHEMATICS

State classification of scientific and technological information

  • 27.21 Geometry

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