Structural features of lymph nodes in different lymphatic regions at the natural and accelerated aging

Владимир Владимирович Попов, Olga Gorchakova, Владимир Николаевич Горчаков, Georgy Demchenko

Research output: Contribution to journalArticlepeer-review

Abstract

The research purpose is to estimate the structural organization of lymph nodes of different localization at natural (physiological) and premature aging respectively at OXYS and Wistar rats. We used a morphological method of a research. The age-induced changes of lymphoid tissue of Wistar and OXYS rats differ with type of the immune response and morphological variant of lymph nodes structure. The immune response on humoral type is formed in mesenteric and inguinal lymph nodes, and the immune response on cellular type is formed in a tracheobronchial lymph node. Structural and functional zones of lymph nodes reach the biggest development in young rats of Wistar. Genetic the defect in rats of OXYS constrains development of peripheral lymphoid organs.We noted reduction of structures of cortical substance, especially lymphoid follicles and a paracortex, and expansion of medullary substance in a lymph node of OXYS rats. Lymph nodes are subject big morphological changes at rats of OXYS, than at old rats of Wistar. Observed changes of structure of lymph nodes of OXYS rats re a morphological equivalent of premature aging and confirms early decrease of a drainage and immune function of lymph nodes.
Translated title of the contributionСтруктурные изменения лимфоузлов разных лимфатических регионов при естественном и преждевременном старении
Original languageEnglish
Article number4
Pages (from-to)19-23
Number of pages5
JournalEuropean Journal of Natural History
Issue number4
Publication statusPublished - 2020

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