Противовирусная активность экстрактов базидиального гриба Daedaleopsis confragosa F-1368

Translated title of the contribution: Antiviral activity of extracts from the daedaleopsis confragosa f-1368 basidiomycete

T. V. Teplyakova, T. N. Ilyicheva, E. D. Danilenko, L. R. Lebedev

Research output: Contribution to journalArticlepeer-review

Abstract

The antiviral activity of extracts of the basidial fungus Daedaleopsis confragosa (Bolton) J. Schröt strain F-1368 cultivated under the laboratory conditions has been studied. It was shown that the extracts obtained from 1 L of the culture contained proteins and polysaccharides in the amount of 71 ± 5 and 413 ± 15 mg/L of culture, respectively. Antiviral activity (ED50) against the pandemic influenza virus A/California/07/09 (H1N1)pdm09 was observed at extract concentrations in the range of 0.02‒0.12 mg/mL depending on the culture medium. The therapeutic index (CC50/ED50) was at the level of 14‒17, which makes it possible to recommend D. confragosa extracts for the development of antiviral agents. It was shown that treatment with hydrolytic enzymes (trypsin, zymolyase) leads to an increase in cytotoxicity and a decrease in the antiviral activity of the extracts.

Translated title of the contributionAntiviral activity of extracts from the daedaleopsis confragosa f-1368 basidiomycete
Original languageRussian
Pages (from-to)21-25
Number of pages5
JournalBiotekhnologiya
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Antiviral activity
  • Basidomycetes
  • Daedaleopsis confragosa
  • Extracts
  • Influenza virus

OECD FOS+WOS

  • 3.01 BASIC MEDICAL RESEARCH
  • 1.05 EARTH AND RELATED ENVIRONMENTAL SCIENCES
  • 1.06 BIOLOGICAL SCIENCES

State classification of scientific and technological information

  • 34 BIOLOGY

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