Проблемы создания вакцин против бетакоронавирусов: антителозависимое усиление инфекции и вирус сендай как возможный вакцинный вектор

Translated title of the contribution: The Challenges of Vaccine Development Against Betacoronaviruses: Antibody Dependent Enhancement and Sendai Virus as a Possible Vaccine Vector

T. A. Zaichuk, Y. D. Nechipurenko, A. A. Adzhubey, S. B. Onikienko, V. A. Chereshnev, S. S. Zainutdinov, G. V. Kochneva, S. V. Netesov, O. V. Matveeva

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

To design an effective and safe vaccine against betacoronaviruses, it is necessary to elicit a combination of strong humoral and cell-mediated immune responses as well as to minimize the risk of antibody-dependent enhancement of viral infection. This phenomenon was observed in animal trials of experimental vaccines against SARS-CoV-1 and MERS-CoV that were developed based on inactivated coronavirus or vector constructs expressing the spike protein (S) of the virion. The substitution and glycosylation of certain amino acids in the antigenic determinants of the S-protein, as well as its conformational changes, can lead to the same effect in a new experimental vaccine against SARS-CoV-2. This review outlines approaches for developing vaccines against the new SARS-CoV-2 coronavirus that are based on non-pathogenic viral vectors. For efficient prevention of infections caused by respiratory pathogens the ability of the vaccine to stimulate mucosal immunity in the respiratory tract is important. Such a vaccine can be developed using non-pathogenic Sendai virus vector, since it can be administered intranasally and induce a mucosal immune response that strengthens the antiviral barrier in the respiratory tract and provides reliable protection against infection. The mucosal immunity and the production of IgA antibodies accompanying its development reduces the likelihood of developing an antibody-dependent infection enhancement, which is usually associated only with immunopathological IgG antibodies.

Translated title of the contributionThe Challenges of Vaccine Development Against Betacoronaviruses: Antibody Dependent Enhancement and Sendai Virus as a Possible Vaccine Vector
Original languageRussian
Pages (from-to)922-938
Number of pages17
JournalMolekuliarnaia biologiia
Volume54
Issue number6
DOIs
Publication statusPublished - 1 Nov 2020

Keywords

  • ADE
  • antibody-dependent enhancement
  • conservative antigenic determinants
  • COVID-19
  • murine respirovirus
  • SARS-CoV-1
  • SARS-CoV-2
  • Sendai virus
  • vaccine vector

State classification of scientific and technological information

  • 34 BIOLOGY

Fingerprint

Dive into the research topics of 'The Challenges of Vaccine Development Against Betacoronaviruses: Antibody Dependent Enhancement and Sendai Virus as a Possible Vaccine Vector'. Together they form a unique fingerprint.

Cite this