Полиморфизм вариантов гена N-ацетилтрансферазы 2 (NAT2) и анализ генной сети

Translated title of the contribution: N-AСetyltransferase (NAT2) gene polymorphism and gene network analysis

Research output: Contribution to journalArticlepeer-review

Abstract

To search for new targets of therapy, it is necessary to reconstruct the gene network of the disease, and identify the interaction of genes, proteins, and drug compounds. Using the online bioinformatics tools we have analyzed the current data set related to the metabolism of xenobiotics, mediated by the N-acetyltransferase 2 (NAT2) gene. The study of allelic polymorphism of the NAT2 gene has a prognostic value, allowing to determine the risk of a number of oncological diseases, the degree of increased risk due to smoking and exposure to chemical carcinogens, including drugs. The aim of this study was to determine the frequencies of two important “slow” variants of the NAT2 gene (NAT2*5, rs1801280 and NAT2*7, rs1799931), which significantly affected the rate of xenobiotic acetylation among the indigenous Nenets population of Northern Siberia. The obtained frequencies of polymorphic variants among the Nenets occupy an intermediate value between those for Europeans and Asians, which might indicate specific features of adaptation. We present a model of the distribution of two polymorphic variants of the NAT2 gene involved in the biotransformation of xenobiotics to study the characteristics of their metabolism in the indigenous inhabitants of Yamal.

Translated title of the contributionN-AСetyltransferase (NAT2) gene polymorphism and gene network analysis
Original languageRussian
Article number4
Pages (from-to)213-221
Number of pages9
JournalBiomeditsinskaya Khimiya
Volume67
Issue number3
DOIs
Publication statusPublished - May 2021

Keywords

  • Bioinformatics
  • Gene networks reconstruction
  • Gene polymorphism
  • N-acetyltransferase 2
  • Nenets
  • Xenobiotics

OECD FOS+WOS

  • 1.06 BIOLOGICAL SCIENCES

State classification of scientific and technological information

  • 34 BIOLOGY

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