Role of air pollution by particulate matter in the pathogenesis of cardiovascular diseases. Prevention measures

A. F. Kolpakova, R. N. Sharipov, O. A. Volkova, F. A. Kolpakov

Research output: Contribution to journalReview articlepeer-review

Abstract

The review highlights contemporary concepts about the role of atmospheric air pollution by particulate matter (PM) in pathogenesis of cardiovascular diseases (CVD). We used publications from the PubMed and Russian Science Citation Index databases. The influence of PM on the development and progression of CVD is considered depending on size, origin, chemical composition, concentration in air. PM with an aerodynamic diameter of ≤2,5 μm (PM2,5) are recognized as the most dangerous. Epidemiological studies have established a dose-dependent effect PM. Oxidative stress, damage of genome of cell and epigenetic changes associated with PM effect are the important component of CVD pathogenesis. Systematization of scientific data through a formalized description helps to understand the pathogenesis of CVD and facilitates its practical use for assessing the risk of occurrence, early diagnosing, prognostication, increasing the effectiveness of treatment, and developing preventive measures.

Translated title of the contributionО роли загрязнения воздуха взвешенными частицами в патогенезе сердечно-сосудистых заболеваний. Меры профилактики
Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalCardiovascular Therapy and Prevention (Russian Federation)
Volume19
Issue number3
DOIs
Publication statusPublished - 1 Mar 2020

Keywords

  • Air pollution
  • Cardiovascular diseases
  • Particulate matter
  • Pathogenesis
  • Preventive measures
  • Review

State classification of scientific and technological information

  • 34.15 Molecular biology

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