Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats

N. Rozhkova; E. Yu Brusentsev; T. N. Igonina; D. S. Ragaeva; O. M. Petrova; V. A. Naprimerov; M. A. Tikhonova; T. G. Amstisiavskaya; S. Ya Amstisiavsky

doi:10.1134/S0044467719050101

Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats

N. Rozhkova, E. Yu Brusentsev, T. N. Igonina, D. S. Ragaeva, O. M. Petrova, V. A. Naprimerov, M. A. Tikhonova, T. G. Amstisiavskaya, S. Ya Amstisiavsky

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Abstract

The purpose of this study was to investigate the effects of maternal exposure to surgical stress at the earliest stages of pregnancy on the number/density of neurons in the prefrontal cortex and in the CA1 and CA3 regions of the hippocampus, as well as on the neurogenesis in the dentate gyrus in the adult OXYS rats. Female OXYS rats were mated at estrus with fertile males of the same strain. After 96 hours since the spermatozoa were found in vaginal smears, the surgery was performed (sham operation simulating embryo transfer). The offspring obtained after maternal surgical exposure (OXYS-PS) were compared with the offspring of intact WAG and OXYS rats at the age of 5 mo. A larger density of neurons was found in the prefrontal cortex in OXYS rats as compared with WAG rats. Moreover, OXYS rats had more pyramidal neurons in the CA1 region and fewer pyramidal neurons in the CA3 region of the hippocampus as compared with WAG rats. There were no significant differences in the intensity of neurogenesis between WAG and OXYS rats. OXYS-PS rats exhibited the reduced number of pyramidal neurons in the prefrontal cortex as compared to both control strains. The density of neurons in the CA1 region of the hippocampus was reduced in the OXYS-PS offspring as compared to WAG and OXYS rats, as well as this density was reduced in the CA3 region in the OXYS-PS offspring as compared to OXYS rats. OXYS-PS rats possessed an enhanced neurogenesis in the dentate gyrus of the hippocampus as compared with intact rats of both strains

Translated title of the contribution	Отсроченные эффекты хирургического воздействия, перенесенного матерью в период ранней беременности, на артериальное давление и поведение потомков у крыс линии OXYS
Original language	English
Pages (from-to)	618-628
Number of pages	11
Journal	Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume	69
Issue number	5
DOIs	https://doi.org/10.1134/S0044467719050101
Publication status	Published - 2019

Keywords

Hippocampus
Long-term effects
Oxys rats
Prefrontal cortex
Pregnancy
Surgery
OXYS rats
long-term effects
hippocampus
CEFTRIAXONE
ABNORMALITIES
prefrontal cortex
BEHAVIOR
pregnancy
DISEASE-LIKE PATHOLOGY
PREIMPLANTATION PERIOD
PRENATAL STRESS
MODEL
UNDERNUTRITION
PREFRONTAL CORTEX
ORIGINS
surgery

State classification of scientific and technological information

34 BIOLOGY

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10.1134/S0044467719050101

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Rozhkova, N., Brusentsev, E. Y., Igonina, T. N., Ragaeva, D. S., Petrova, O. M., Naprimerov, V. A., Tikhonova, M. A., Amstisiavskaya, T. G., & Amstisiavsky, S. Y. (2019). Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, 69(5), 618-628. https://doi.org/10.1134/S0044467719050101

Rozhkova, N. ; Brusentsev, E. Yu ; Igonina, T. N. ; Ragaeva, D. S. ; Petrova, O. M. ; Naprimerov, V. A. ; Tikhonova, M. A. ; Amstisiavskaya, T. G. ; Amstisiavsky, S. Ya. / Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats. In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2019 ; Vol. 69, No. 5. pp. 618-628.

@article{d8083547d4f84eac96546ff278791275,

title = "Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats",

abstract = "The purpose of this study was to investigate the effects of maternal exposure to surgical stress at the earliest stages of pregnancy on the number/density of neurons in the prefrontal cortex and in the CA1 and CA3 regions of the hippocampus, as well as on the neurogenesis in the dentate gyrus in the adult OXYS rats. Female OXYS rats were mated at estrus with fertile males of the same strain. After 96 hours since the spermatozoa were found in vaginal smears, the surgery was performed (sham operation simulating embryo transfer). The offspring obtained after maternal surgical exposure (OXYS-PS) were compared with the offspring of intact WAG and OXYS rats at the age of 5 mo. A larger density of neurons was found in the prefrontal cortex in OXYS rats as compared with WAG rats. Moreover, OXYS rats had more pyramidal neurons in the CA1 region and fewer pyramidal neurons in the CA3 region of the hippocampus as compared with WAG rats. There were no significant differences in the intensity of neurogenesis between WAG and OXYS rats. OXYS-PS rats exhibited the reduced number of pyramidal neurons in the prefrontal cortex as compared to both control strains. The density of neurons in the CA1 region of the hippocampus was reduced in the OXYS-PS offspring as compared to WAG and OXYS rats, as well as this density was reduced in the CA3 region in the OXYS-PS offspring as compared to OXYS rats. OXYS-PS rats possessed an enhanced neurogenesis in the dentate gyrus of the hippocampus as compared with intact rats of both strains",

keywords = "Hippocampus, Long-term effects, Oxys rats, Prefrontal cortex, Pregnancy, Surgery, OXYS rats, long-term effects, hippocampus, CEFTRIAXONE, ABNORMALITIES, prefrontal cortex, BEHAVIOR, pregnancy, DISEASE-LIKE PATHOLOGY, PREIMPLANTATION PERIOD, PRENATAL STRESS, MODEL, UNDERNUTRITION, PREFRONTAL CORTEX, ORIGINS, surgery",

author = "N. Rozhkova and Brusentsev, {E. Yu} and Igonina, {T. N.} and Ragaeva, {D. S.} and Petrova, {O. M.} and Naprimerov, {V. A.} and Tikhonova, {M. A.} and Amstisiavskaya, {T. G.} and Amstisiavsky, {S. Ya}",

note = "Рожкова И.Н., Брусенцева Е.Ю., Игонина Т.Н., Рагаева Д.С., Петрова О.М., Напримеров В.А., Тихонова М.А., Амстиславская Т.Г., Амстиславский С.Я. Отсроченные эффекты хирургического воздействия, перенесенного матерью в период ранней беременности, на артериальное давление и поведение потомков у крыс линии OXYS // Журнал высшей нервной деятельности им. И.П. Павлова. - 2019. - Т. 69. - № 5. - С. 618-628",

year = "2019",

doi = "10.1134/S0044467719050101",

language = "English",

volume = "69",

pages = "618--628",

journal = "Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova",

issn = "0044-4677",

publisher = "MEZHDUNARODNAYA KNIGA",

number = "5",

}

Rozhkova, N, Brusentsev, EY, Igonina, TN, Ragaeva, DS, Petrova, OM, Naprimerov, VA, Tikhonova, MA , Amstisiavskaya, TG & Amstisiavsky, SY 2019, 'Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats', Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, vol. 69, no. 5, pp. 618-628. https://doi.org/10.1134/S0044467719050101

Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats. / Rozhkova, N.; Brusentsev, E. Yu; Igonina, T. N.; Ragaeva, D. S.; Petrova, O. M.; Naprimerov, V. A.; Tikhonova, M. A.; Amstisiavskaya, T. G.; Amstisiavsky, S. Ya.

In: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Vol. 69, No. 5, 2019, p. 618-628.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats

AU - Rozhkova, N.

AU - Brusentsev, E. Yu

AU - Igonina, T. N.

AU - Ragaeva, D. S.

AU - Petrova, O. M.

AU - Naprimerov, V. A.

AU - Tikhonova, M. A.

AU - Amstisiavskaya, T. G.

AU - Amstisiavsky, S. Ya

N1 - Рожкова И.Н., Брусенцева Е.Ю., Игонина Т.Н., Рагаева Д.С., Петрова О.М., Напримеров В.А., Тихонова М.А., Амстиславская Т.Г., Амстиславский С.Я. Отсроченные эффекты хирургического воздействия, перенесенного матерью в период ранней беременности, на артериальное давление и поведение потомков у крыс линии OXYS // Журнал высшей нервной деятельности им. И.П. Павлова. - 2019. - Т. 69. - № 5. - С. 618-628

PY - 2019

Y1 - 2019

N2 - The purpose of this study was to investigate the effects of maternal exposure to surgical stress at the earliest stages of pregnancy on the number/density of neurons in the prefrontal cortex and in the CA1 and CA3 regions of the hippocampus, as well as on the neurogenesis in the dentate gyrus in the adult OXYS rats. Female OXYS rats were mated at estrus with fertile males of the same strain. After 96 hours since the spermatozoa were found in vaginal smears, the surgery was performed (sham operation simulating embryo transfer). The offspring obtained after maternal surgical exposure (OXYS-PS) were compared with the offspring of intact WAG and OXYS rats at the age of 5 mo. A larger density of neurons was found in the prefrontal cortex in OXYS rats as compared with WAG rats. Moreover, OXYS rats had more pyramidal neurons in the CA1 region and fewer pyramidal neurons in the CA3 region of the hippocampus as compared with WAG rats. There were no significant differences in the intensity of neurogenesis between WAG and OXYS rats. OXYS-PS rats exhibited the reduced number of pyramidal neurons in the prefrontal cortex as compared to both control strains. The density of neurons in the CA1 region of the hippocampus was reduced in the OXYS-PS offspring as compared to WAG and OXYS rats, as well as this density was reduced in the CA3 region in the OXYS-PS offspring as compared to OXYS rats. OXYS-PS rats possessed an enhanced neurogenesis in the dentate gyrus of the hippocampus as compared with intact rats of both strains

AB - The purpose of this study was to investigate the effects of maternal exposure to surgical stress at the earliest stages of pregnancy on the number/density of neurons in the prefrontal cortex and in the CA1 and CA3 regions of the hippocampus, as well as on the neurogenesis in the dentate gyrus in the adult OXYS rats. Female OXYS rats were mated at estrus with fertile males of the same strain. After 96 hours since the spermatozoa were found in vaginal smears, the surgery was performed (sham operation simulating embryo transfer). The offspring obtained after maternal surgical exposure (OXYS-PS) were compared with the offspring of intact WAG and OXYS rats at the age of 5 mo. A larger density of neurons was found in the prefrontal cortex in OXYS rats as compared with WAG rats. Moreover, OXYS rats had more pyramidal neurons in the CA1 region and fewer pyramidal neurons in the CA3 region of the hippocampus as compared with WAG rats. There were no significant differences in the intensity of neurogenesis between WAG and OXYS rats. OXYS-PS rats exhibited the reduced number of pyramidal neurons in the prefrontal cortex as compared to both control strains. The density of neurons in the CA1 region of the hippocampus was reduced in the OXYS-PS offspring as compared to WAG and OXYS rats, as well as this density was reduced in the CA3 region in the OXYS-PS offspring as compared to OXYS rats. OXYS-PS rats possessed an enhanced neurogenesis in the dentate gyrus of the hippocampus as compared with intact rats of both strains

KW - Hippocampus

KW - Long-term effects

KW - Oxys rats

KW - Prefrontal cortex

KW - Pregnancy

KW - Surgery

KW - OXYS rats

KW - long-term effects

KW - hippocampus

KW - CEFTRIAXONE

KW - ABNORMALITIES

KW - prefrontal cortex

KW - BEHAVIOR

KW - pregnancy

KW - DISEASE-LIKE PATHOLOGY

KW - PREIMPLANTATION PERIOD

KW - PRENATAL STRESS

KW - MODEL

KW - UNDERNUTRITION

KW - PREFRONTAL CORTEX

KW - ORIGINS

KW - surgery

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U2 - 10.1134/S0044467719050101

DO - 10.1134/S0044467719050101

M3 - Article

AN - SCOPUS:85073580869

VL - 69

SP - 618

EP - 628

JO - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

JF - Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova

SN - 0044-4677

IS - 5

ER -

Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats

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