Long-term effects of maternal exposure to surgery at the earliest stage of pregnancy on the brain development in oxys rats

N. Rozhkova, E. Yu Brusentsev, T. N. Igonina, D. S. Ragaeva, O. M. Petrova, V. A. Naprimerov, M. A. Tikhonova, T. G. Amstisiavskaya, S. Ya Amstisiavsky

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Abstract

The purpose of this study was to investigate the effects of maternal exposure to surgical stress at the earliest stages of pregnancy on the number/density of neurons in the prefrontal cortex and in the CA1 and CA3 regions of the hippocampus, as well as on the neurogenesis in the dentate gyrus in the adult OXYS rats. Female OXYS rats were mated at estrus with fertile males of the same strain. After 96 hours since the spermatozoa were found in vaginal smears, the surgery was performed (sham operation simulating embryo transfer). The offspring obtained after maternal surgical exposure (OXYS-PS) were compared with the offspring of intact WAG and OXYS rats at the age of 5 mo. A larger density of neurons was found in the prefrontal cortex in OXYS rats as compared with WAG rats. Moreover, OXYS rats had more pyramidal neurons in the CA1 region and fewer pyramidal neurons in the CA3 region of the hippocampus as compared with WAG rats. There were no significant differences in the intensity of neurogenesis between WAG and OXYS rats. OXYS-PS rats exhibited the reduced number of pyramidal neurons in the prefrontal cortex as compared to both control strains. The density of neurons in the CA1 region of the hippocampus was reduced in the OXYS-PS offspring as compared to WAG and OXYS rats, as well as this density was reduced in the CA3 region in the OXYS-PS offspring as compared to OXYS rats. OXYS-PS rats possessed an enhanced neurogenesis in the dentate gyrus of the hippocampus as compared with intact rats of both strains

Translated title of the contributionОтсроченные эффекты хирургического воздействия, перенесенного матерью в период ранней беременности, на артериальное давление и поведение потомков у крыс линии OXYS
Original languageEnglish
Pages (from-to)618-628
Number of pages11
JournalZhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume69
Issue number5
DOIs
Publication statusPublished - 2019

Keywords

  • Hippocampus
  • Long-term effects
  • Oxys rats
  • Prefrontal cortex
  • Pregnancy
  • Surgery
  • OXYS rats
  • long-term effects
  • hippocampus
  • CEFTRIAXONE
  • ABNORMALITIES
  • prefrontal cortex
  • BEHAVIOR
  • pregnancy
  • DISEASE-LIKE PATHOLOGY
  • PREIMPLANTATION PERIOD
  • PRENATAL STRESS
  • MODEL
  • UNDERNUTRITION
  • PREFRONTAL CORTEX
  • ORIGINS
  • surgery

State classification of scientific and technological information

  • 34 BIOLOGY

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