Особенности образование антител против бензо[а]пирена у работников угольных шахт и теплоэлектростанций

Translated title of the contribution: Features of antibodies against benzo[a]pyrene formation in workers of coal mines and thermal power plants

Yelena G. Polenok, Stella A. Mun, Lyudmila A. Gordeeva, Anton A. Glushkov, Mikhail V. Kostyanko, Ilgiz A. Vafin

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. Coal dust and coal firing products contain large amounts of carcinogenic chemicals (specifically benz[a] pyrene) that are different in influence on workers of coal mines and thermal power plants. Specific immune reactions to benz[a]pyrene therefore in these categories of workers can have specific features. Objective. To reveal features of antibodies specific to benz[a]pyrene formation in workers of coal mines and thermal power plants. Materials and methods. The study covered A and G class antibodies against benz[a]pyrene (IgA-Bp and IgG-Bp) in serum of 705 males: 213 donors of Kemerovo blood transfusion center (group 1, reference); 293 miners (group 2) and 199 thermal power plant workers (group 3). Benz[a]pyrene conjugate with bovine serum albumin as an adsorbed antigen was subjected to immune-enzyme assay. Results. IgA-Bp levels in the miners (Me = 2.7) did not differ from those in the reference group (Me = 2.9), but in the thermal power plant workers (Me = 3.7) were reliably higher than those in healthy men and in the miners (p<0.0001). Levels of IgG-Bp in the miners (Me = 5.0) appeared to be lower than those in the reference group (Me = 6.4; (p = 0.05). IgG-Bb level in the thermal power plant workers (Me = 7.4) exceeded the parameters in the healthy donors and the miners (p<0.0001). Non-industrial factors (age and smoking) appeared to have no influence on specific immune reactions against benz[a]pyrene in the miners and the thermal power plant workers. Conclusions. Specific immune reactions against benz[a]pyrene in the miners and the thermal power plant workers are characterized by peculiarities: the miners demonstrate lower levels of class A serum antibodies to benz[a]pyrene; the thermal power plant workers present increased serum levels of class G antibodies to benz[a]pyrene. These peculiarities result from only the occupational features, but do not depend on such factors as age, smoking and length of service at hazardous production. It is expedient to study specific immune reactions to benz[a]pyrene in workers of coal mines and thermal power plants, to evaluate individual oncologic risk and if malignancies occur.

Translated title of the contributionFeatures of antibodies against benzo[a]pyrene formation in workers of coal mines and thermal power plants
Original languageRussian
Article number2
Pages (from-to)9-14
Number of pages6
JournalMeditsina Truda I Promyshlennaya Ekologiya
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • Antibodies
  • Benz[a]pyrene
  • Workers of coal mines and thermal power plants

State classification of scientific and technological information

  • 76 MEDICINE AND HEALTH CARE

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