Oncolytic Paramyxoviruses: Mechanism of Action, Preclinical and Clinical Studies

O. V. Matveeva, G. V. Kochneva, S. S. Zainutdinov, G. V. Ilyinskaya, P. M. Chumakov

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Preclinical studies demonstrate that a broad spectrum of human and animal malignant cells can be killed by oncolytic paramyxoviruses, which includes cells of ecto-, endo- and mesodermal origin. In clinical trials, significant reduction or even complete elimination of primary tumors and established metastases has been reported. Different routes of virus administration (intratumoral, intravenous, intradermal, intraperito-neal, or intrapleural) and single- vs. multiple-dose administration schemes have been explored. The reported side effects were grades 1 and 2, with the most common among them being mild fever. There are certain advantages in using paramyxoviruses as oncolytic agents compared to members of other virus families exist. Thanks to cytoplasmic replication, paramyxoviruses do not integrate the host genome or engage in recombination, which makes them safer and more attractive candidates for widely used therapeutic oncolysis than ret-roviruses or some DNA viruses. The list of oncolytic Paramyxoviridae members includes the attenuated measles virus, mumps virus, low pathogenic Newcastle disease, and Sendai viruses. Metastatic cancer cells frequently overexpress certain surface molecules that can serve as receptors for oncolytic paramyxoviruses. This promotes specific viral attachment to these malignant cells. Paramyxoviruses are capable of inducing efficient syncytium-mediated lysis of cancer cells and elicit strong immune stimulation, which dramatically enforces anticancer immune surveillance. In general, preclinical studies and phases I-III of clinical trials yield very encouraging results and warrant continued research of oncolytic paramyxoviruses as a particularly valuable addition to the existing panel of cancer-fighting approaches.

Translated title of the contributionОнколитические парамиксовирусы: Механизм действия, доклинические и клинические исследования
Original languageEnglish
Pages (from-to)360-379
Number of pages20
JournalMolekuliarnaia biologiia
Volume52
Issue number3
DOIs
Publication statusPublished - 11 Jul 2018

Keywords

  • anticancer immunity
  • anticancer mechanism
  • cancer therapy
  • mumps virus
  • Newcastle disease virus
  • oncolytic paramyxoviruses
  • Sendai virus
  • therapy of malignant tumors
  • vaccine strain of measles virus
  • viral oncolysis

State classification of scientific and technological information

  • 34 BIOLOGY

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