Нейротрофический фактор мозга (BDNF) и его диагностическая значимость при измерении в крови: аналитический обзор

Translated title of the contribution: Brain-derived neurotrophic factor (BDNF) and its diagnostic significance when measured in blood: analitical review

A. A. Shvaikovskaya, S. Y. Zhanaeva, A. Evsyukova, M. A. Tikhonova, K. Danilenko, L. Aftanas

Research output: Contribution to journalReview articlepeer-review

Abstract

Brain neurotrophic factor (BDNF) is one of the key indicators of neurogenesis and neuroplasticity. The concentration of BDNF in the blood is positioned as a potential biomarker of the development and dynamics of neuropsychiatric diseases. However, the extent to which its concentration in the blood reflects its content in the brain is not clear; a literature analysis on this matter has not been performed.

This review provides basic information about the biological role, content and regulation of BDNF in the body (chapter I), about the concentration of BDNF in the blood in neuropsychiatric diseases (chapter II), and analyzes the correlation of BDNF content in the brain and blood (chapter III, the main one).

In 5 out of 6 studies on intact animals identified as a result of the literature search, a statistically significant positive correlation between the concentration of BDNF in the brain and blood is reported. However, the correlation coefficient is variable and generally not high - from 0.40 to 0.83. There were no during-life studies performed in human. Some post-mortem studies have reported a significant association between BDNF indices values in the brain and in the periphery. Thus, the question of the extent to which BDNF in the blood is diagnostically valuable remains unanswered.

Translated title of the contributionBrain-derived neurotrophic factor (BDNF) and its diagnostic significance when measured in blood: analitical review
Original languageRussian
Pages (from-to)105-110
Number of pages6
JournalYakut medical journal
Issue number3
DOIs
Publication statusPublished - 2020

Keywords

  • human
  • brain-derived neurotrophic factor (BDNF)
  • neuropsychiatric diseases
  • brain
  • blood
  • correlation between brain and blood
  • PARKINSONS-DISEASE
  • ALZHEIMERS-DISEASE
  • MESSENGER-RNA
  • SERUM
  • RAT
  • EXPRESSION
  • EPILEPSY
  • PROTEIN
  • MODEL
  • NEUROGENESIS

State classification of scientific and technological information

  • 34 BIOLOGY

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