Механохимический синтез смешанных кристаллов бетулина с адипиновой кислотой

Translated title of the contribution: Mechanochemical Synthesis of Cocrystals of Betulin with Adipic Acid

Svetlana A. Myz, Mikhail A. Mikhailenko, Anastasiya Mikhailovskaya, Anatoly A. Politov, Svetlana A. Kuznetsova, Tatyana P. Shakhtshneider

Research output: Contribution to journalArticlepeer-review

Abstract

The cocrystal of betulin with adipic acid was prepared using a liquid-assisted grinding method. The formation of cocrystal was confirmed by powder X-ray diffraction and IR spectroscopy methods. In order to choose a liquid for preparing cocrystal, solvents of different polarity were compared. It was shown that cocrystal of betulin with adipic acid was formed if solvents were used during mechanical treatment, in which the increased solubility of adipic acid was observed.

Translated title of the contributionMechanochemical Synthesis of Cocrystals of Betulin with Adipic Acid
Original languageRussian
Article number5
Pages (from-to)511-524
Number of pages14
JournalЖурнал Сибирского федерального университета. Серия: Химия.
Volume13
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • mechanochemical synthesis
  • betulin
  • cocrystals
  • adipic acid
  • PHARMACEUTICAL COCRYSTALS
  • ORGANIC-SOLVENTS
  • X-RAY
  • SOLUBILITY
  • SOLVATOMORPHS
  • FORMS
  • Betulin
  • Cocrystals
  • Mechanochemical synthesis
  • Adipic acid

State classification of scientific and technological information

  • 31 CHEMISTRY

Fingerprint

Dive into the research topics of 'Mechanochemical Synthesis of Cocrystals of Betulin with Adipic Acid'. Together they form a unique fingerprint.

Cite this