Комплексная оценка изменений свертывающей системы крови в периоперационном периоде при эмболизации маточных артерий

Translated title of the contribution: Integrated assessment of perioperative changes in the blood coagulating system during uterine artery embolization

Irina P. Syutkina, Dmitriy V. Khabarov, Fedor A. Rakitin, Marya V. Kochetkova, Alisa D. Ineshina

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To assess the time course of perioperative changes in the blood coagulation system during uterine artery embolization (EMA) based on monitoring the indicators of the hemostatic system, including thromboelastography (TEG), and to identify a thrombogenic propensity (or absence. Subjects and methods. The investigation enrolled 37 female patients with EMA, in whom the risk factors predisposing to thromboembolic events were excluded during preoperative examination. Dynamic monitoring of coagulography and TEG measures was performed in the perioperative period. Results. A day after EMA, the patients tended to have hypercoagulation, as evidenced by TEG (decreases in R time and K time and increases in α-angle and maximum amplitude), as well as activation of fibrinolysis (an increase in LY 30 levels). At the same time, a study of coagulogram indices revealed increases in the level of hypercoagulability markers (fibrinogen, D-dimer, soluble fibrin-monomer complexes) and in prothrombin index and a decrease in activated partial thromboplastin time. The findings generally suggest that there is an increased risk for venous thromboembolic events (VTEE) in the postoperative period after EMA. Conclusion. The revealed features of hemostasiological changes in patients after EMA suggest that there is a need for the continuous monitoring of the hemostatic system and the development of effective preventive measures for VTEE.

Translated title of the contributionIntegrated assessment of perioperative changes in the blood coagulating system during uterine artery embolization
Original languageRussian
Article number19
Pages (from-to)133-139
Number of pages7
JournalAkusherstvo i Ginekologiya (Russian Federation)
Volume2019
Issue number12
DOIs
Publication statusPublished - 2019

Keywords

  • Hemostasis
  • Thromboelastography
  • Thromboembolic events
  • Uterine artery embolization

OECD FOS+WOS

  • 3.02 CLINICAL MEDICINE
  • 3.02.SD OBSTETRICS & GYNECOLOGY

State classification of scientific and technological information

  • 76.29 Clinical medicine

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