Клиническое значение изучения генетического полиморфизма факторов адгезии при Helicobacter pylori-ассоциированных заболеваниях

Translated title of the contribution: Clinical significance of studying the genetic polymorphism of adhesion factors in Helicobacter pylori-associated diseases

Galina I. Lifshits, Evgeniya V. Shrayner, Nataliya V. Kokh, Elena N. Voronina, Anatoly I. Khavkin

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the work was to study the clinical significance of the genetic polymorphism of the adhesion factor - the genetic locus rs602662 FUT2 in Helicobacter pylori-associated diseases. Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a“Real-Time CFX96 Touch”amplifier. The duration of the study was 6 months. Results: When assessing the contribution of the genotype of the rs602662 locus of the FUT2 gene as a risk factor for the occurrence of clinical manifestations in H. pylori infection, it was found that the A allele has a protective effect on the occurrence of clinical symptoms of dyspepsia. The odds ratio (OR) for allele “A” carriers (genotypes A/A and G/A versus G/G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI=[0.049-0.625] chi2=7.79 p=0.0053). Conclusion. As a result of the study, it was revealed that the carriage of the “A” allele has a significant associative relationship with the absence of clinical symptoms in patients with H. pylori infection 0.175 (C.I.= [0.049-0.625] chi2=7.79 p=0.0053).

Translated title of the contributionClinical significance of studying the genetic polymorphism of adhesion factors in Helicobacter pylori-associated diseases
Original languageRussian
Article number3
Pages (from-to)18-23
Number of pages6
JournalEksperimental'naya i Klinicheskaya Gastroenterologiya
Volume197
Issue number1
DOIs
Publication statusPublished - 2022

OECD FOS+WOS

  • 3.02 CLINICAL MEDICINE

State classification of scientific and technological information

  • 76 MEDICINE AND HEALTH CARE

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