Changes in Gene Expression and Neuroinflammation in the Hippocampus after Focal Brain Ischemia: Involvement in the Long-Term Cognitive and Mental Disorders

Galina T. Shishkina, Tatiana S. Kalinina, Natalia V. Gulyaeva, Dmitry A. Lanshakov, Nikolay N. Dygalo

Research output: Contribution to journalReview articlepeer-review

Abstract

Ischemic brain injuries are accompanied by the long-term changes in gene expression in the hippocampus, the limbic system structure, involved in the regulation of key aspects of the higher nervous activity, such as cognitive functions and emotions. The altered expression of genes and proteins encoded by them may be related to the development of post-ischemic psycho-emotional and cognitive disturbances. Activation of neuroinflammation following stroke in the hippocampus has been suggested to play an essential role in induction of long-lasting consequences. Identification of changes in the gene expression patterns after ischemia and investigation of the dynamics of these changes in the hippocampus are the necessary first steps toward understanding molecular pathways responsible for the development of post-stroke cognitive impairments and mental pathologies.

Translated title of the contributionИзменение экспрессии генов и нейровоспаление в гиппокампе после фокальной ишемии мозга: участие в индукции длительных когнитивных и психоэмоциональных нарушений
Original languageEnglish
Article number3
Pages (from-to)657-666
Number of pages10
JournalBiochemistry (Moscow)
Volume86
Issue number6
DOIs
Publication statusPublished - Jun 2021
Externally publishedYes

Keywords

  • cognitive impairment
  • depression
  • focal brain injuries
  • gene expression
  • hippocampus
  • neuroinflammation
  • Stroke/complications
  • Mental Disorders/etiology
  • Humans
  • Gene Expression Regulation
  • Cognition Disorders/etiology
  • Cognition
  • Inflammation
  • Animals
  • Brain Ischemia/complications
  • Brain Injuries
  • Hippocampus/metabolism
  • Depression/etiology

OECD FOS+WOS

  • 1.06.CQ BIOCHEMISTRY & MOLECULAR BIOLOGY

State classification of scientific and technological information

  • 34 BIOLOGY

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