Изменение транскрипции генов Fgf9, Fgfr3, с-Мyc и FoxG1 в развивающемся мозге мышей с нокаутом гена Zbtb33

Translated title of the contribution: Zbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3, с-Мус and FoxG1 Genes in the Developing Mouse Brain

N. B. Illarionova, M. A. Borisova, E. Y. Bazhenova, D. S. Zabelina, D. V. Fursenko, A. V. Kulikov

Research output: Contribution to journalArticlepeer-review

Abstract

The transcription factor KAISO is important for proper development of animal embryos. In the cell, KAISO regulates cell division and apoptosis. KAISO is abundant in the central nervous system. Here we describe the effects of Zbtb33 gene knockout on the transcription of several genes that regulate the development of the central nervous system, including Fgf9, Fgfr3, Sox9, Sox2, c-Myc, NeuroD1 and FoxG1. These genes are related to the Wnt/β-catenin signaling pathway, which is closely connected to KAISO. Hippocampal, frontal cortical, and striatal tissue from C57BL/6j mice with a knockout in the Zbtb33 gene encoding KAISO (ZBTB33-) and wild-type mice (ZBTB33+) were collected and profiled at different stages of development. Age-dependent and region-specific differences in the mRNA levels of the Fgf9, Fgfr3, c-Myc, FoxG1 genes in the developing brain of ZBTB33- and ZBTB33+ mice were described and discussed.

Translated title of the contributionZbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3, с-Мус and FoxG1 Genes in the Developing Mouse Brain
Original languageRussian
Article number6
Pages (from-to)422-430
Number of pages9
JournalMolekuliarnaia biologiia
Volume55
Issue number3
DOIs
Publication statusPublished - 1 May 2021

Keywords

  • c-Myc
  • Fgf9
  • Fgfr3
  • FoxG1
  • frontal cortex
  • hippocampus
  • Kaiso
  • mouse
  • Real-time PCR
  • striatum
  • Wnt/β-catenin signaling

OECD FOS+WOS

  • 3.02 CLINICAL MEDICINE

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