Functional magnetic resonance imaging (fMRI) provides a unique opportunity for non-invasive dynamic assessment of the activity of brain structures with high spatial resolution. Integration of neuroimaging data and genetic information allows a deeper understanding of the principles of the brain activity. The review presents recent work devoted to the study of the genetic basis of the organization of the brain and the mechanisms of neuropsychiatric diseases using fMRI. In particular, associations of a transcriptome with a structural connectome in animals and humans are considered. It is shown that the global network architecture is essentially inheritable. The influence of genes determining neurophysiological processes at the cellular and subcellular levels on the parameters of global brain activity, including the structure of resting state networks, has been characterized.
State classification of scientific and technological information
- 34.39 Physiology of humans and animals