Выявление однонуклеотидных полиморфизмов в ассоциированных с митохондриями генах, способных влиять на развитие гипертрофической кардиомиопатии у преждевременно стареющих крыс OXYS

Translated title of the contribution: Assessment of mitochondria-associated genes for single nucleotide polymorphisms linked to the development of hypertrophic cardiomyopathy in the senescence-accelerated OXYS rats

V. A. Devyatkin, N. A. Muraleva, N. G. Kolosova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Hypertrophic cardiomyopathy (HС) is a heterogeneous myocardial disease with a wide range of clinical manifestations and risk of development increasing with age along with myocardial changes characteristic of aging. The contribution of genetic component to the development of HC is obvious, however, the etiology and pathogenesis of this disease remains unclear in 50% of cases. The aim of the present study was to search for single nucleotide polymorphisms (SNPs) in mitochondria-associated genes that can contribute to the development of myocardial hypertrophy using RNA-Seq data from senescence-accelerated OXYS rats. Here we revealed SNPs with a possible negative effect on the function of the protein product in mitochondria-associated genes Fbxl4 and Slc25a32, mutations in which were not previously associated with HC. Alterations in the expression of these genes in the myocardium of OXYS rats at different stages of the development of pathological changes indicate that the revealed SNPs can contribute to the development of HC. Thus, SNPs in the Fbxl4 and Slc25a32 genes, as well as the genes themselves, can be considered promising molecular targets in the studies of the contribution of mitochondrial dysfunction to the development of myocardial hypertrophy.

Translated title of the contributionAssessment of mitochondria-associated genes for single nucleotide polymorphisms linked to the development of hypertrophic cardiomyopathy in the senescence-accelerated OXYS rats
Original languageRussian
Pages (from-to)901-907
Number of pages7
JournalAdvances in gerontology = Uspekhi gerontologii
Volume32
Issue number6
Publication statusPublished - 1 Dec 2019

Keywords

  • aging
  • Fbxl4
  • myocardial hypertrophy
  • OXYS rats
  • single-nucleotide polymorphisms
  • Slc25a32

State classification of scientific and technological information

  • 34.23 Genetics

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