Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.
|Translated title of the contribution||Влияние дексаметазона и гипоксии на содержание активной каспазы-3 в мозжечке и поведение неонатальных крысят|
|Number of pages||5|
|Publication status||Published - 5 Nov 2014|
- 1.06 BIOLOGICAL SCIENCES
State classification of scientific and technological information
- 34 BIOLOGY