The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats

V. V. Bulygina; P. N. Men’shanov; D. A. Lanshakov; N. N. Dygalo

doi:10.1134/S1062359014060028

The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats

V. V. Bulygina, P. N. Men’shanov, D. A. Lanshakov, N. N. Dygalo

Physiology Section

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Abstract

Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.

Translated title of the contribution	Влияние дексаметазона и гипоксии на содержание активной каспазы-3 в мозжечке и поведение неонатальных крысят
Original language	English
Article number	8
Pages (from-to)	540-544
Number of pages	5
Journal	Biology Bulletin
Volume	41
Issue number	6
DOIs	https://doi.org/10.1134/S1062359014060028
Publication status	Published - 5 Nov 2014

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title = "The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats",

abstract = "Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.",

author = "Bulygina, {V. V.} and Men{\textquoteright}shanov, {P. N.} and Lanshakov, {D. A.} and Dygalo, {N. N.}",

note = "Funding Information: ACKNOWLEDGMENTS This study was supported by the Russian Founda tion for Basic Research, projects nos. 12 04 01069 a and 14 04 31447 mol_a. Publisher Copyright: {\textcopyright} 2014, Pleiades Publishing, Inc.",

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AU - Lanshakov, D. A.

AU - Dygalo, N. N.

N1 - Funding Information: ACKNOWLEDGMENTS This study was supported by the Russian Founda tion for Basic Research, projects nos. 12 04 01069 a and 14 04 31447 mol_a. Publisher Copyright: © 2014, Pleiades Publishing, Inc.

PY - 2014/11/5

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N2 - Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.

AB - Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.

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The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats

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