Abstract
Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.
| Translated title of the contribution | The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats |
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| Original language | Russian |
| Article number | 8 |
| Pages (from-to) | 616-620 |
| Number of pages | 5 |
| Journal | Izvestiia Akademii nauk. Seriia biologicheskaia / Rossiĭskaia akademiia nauk |
| Issue number | 6 |
| Publication status | Published - 1 Nov 2014 |
OECD FOS+WOS
- 1.06 BIOLOGICAL SCIENCES
State classification of scientific and technological information
- 34 BIOLOGY