Abstract

Normally, in human cells, both DNA single- strand breaks (SSBs) and double-strand breaks (DSBs) arising due to exogenous and endogenous DNA damaging agents, are efficiently repaired by base excision repair (BER) and several DSB repair pathways, correspondingly. However, mutations in genes involved in DNA repair or extensive DNA damage caused by exogenous or endogenous mutagens may lead to the accumulation of unrepaired DNA strand breaks (SBs). Accumulation of the persistent SBs results in genomic instability and may lead to many human diseases including cancer. Unlike BER deficiency, that causes downregulation of NHEJ genes and initiates cell death, the knockdown of XRCC4, key NHEJ gene has a less dramatic effect on the expression of BER genes.
Translated title of the contributionВзаимодействие между системами репарации NHEJ и BER в NHEJ - дефицитных клетках
Original languageEnglish
Pages589
Number of pages1
DOIs
Publication statusPublished - 2020
EventBioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) - ICG SB RAS, Новосибирск, Russian Federation
Duration: 6 Jul 202010 Jul 2020
Conference number: 12
https://bgrssb.icgbio.ru/2020/

Conference

ConferenceBioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)
Abbreviated titleBGRS/SB-2020
CountryRussian Federation
CityНовосибирск
Period06.07.202010.07.2020
Internet address

Keywords

  • DNA DAMAGE, BASE EXCISION REPAIR (BER), NON- HOMOLOGOUS END JOINING (NHEJ), TRANSCRIPTION FACTOR SP1

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