Бор-нейтронозахватная терапия глиобластомы человека на моделях опухоли in vivo

Translated title of the contribution: BORON NEUTRON CAPTURE THERAPY FOR HUMAN GLIOBLASTOMA ININ VIVO TUMOR MODELS

Research output: Contribution to journalArticle

Abstract

In recent years, there has been an increase in the frequency of diagnosed brain tumors, in particular of the most malignant of them, glioblastomas. Unsatisfactory results of treatment of patients with glioblastoma attract the attention of practitioners to new methods of treatment. The paper highlights the results of in vivo studies in the field of boron neutron capture therapy (BNCT) using the accelerator based epithermal neutron source of the Budker Institute of Nuclear Physics, SB RAS. The U87 human glioblastoma cell line was used for the experiments. Experimental models were 8-week-old immunodeficient male SCID mice with intracranial inoculation of tumor cells, as well as Nu/Jc mice with subcutaneous injection of U87 line cells. Borphenylalanine (BPA) and borcaptat (BSH) were used as drugs. Experimental research data have shown that BNCT reduces and in some cases stops the tumor growth. The results demonstrate that the average life expectancy after BNCT is higher in experimental groups with BSH than in those with BPA and in the control group
Original languageRussian
JournalСовременные проблемы науки и образования
Issue number1
DOIs
Publication statusPublished - 25 Jan 2019

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State classification of scientific and technological information

  • 76 MEDICINE AND HEALTH CARE
  • 76.29 Clinical medicine

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