Аллельные полиморфизмы транспортера серотонина как фактор формирования когнитивного контроля над поведением у якутов

Translated title of the contribution: Allelic polymorphism of the serotonin transporter as a formation factor of the behavioral cognitive control in the Yakuts

A. G. Karpova, A. N. Savostyanov, D. V. Bazovkina, S. S. Tamozhnikov, A. E. Saprygin, E. A. Proshina, N. V. Borisova, L. I. Aftanas

Research output: Contribution to journalArticlepeer-review

Abstract

Allelic polymorphism of serotonin transporter 5-HTTLPR is connected with higher risk of vulnerabil-ity to the mental pathologies, which are associated with disorders in regulation of emotional behavior. However, the influence of this polymorphism on predisposition to disorders significantly differs in the different ethnic groups. The aim of our study is an exploration of the 5-HTTLPR effects on the change of theta-band spectral power in EEG in condition of recognition of the written emotional sentences in the Yakuts in comparison with the Russians. 78 healthy Yakutian students and 82 healthy Russian students participated in the study. In EEG experiment, the participants recognized a grammatical error in the Russian written sentences. The sentences contained a hidden condition, which was not clearly announced to participants: - some of sentences described unanimated objects, own anxiety of participant, anxiety of other persons, own aggression of participant or aggression of other persons. The probes of blood or buccal epithelium were taken in each participant for genetic analysis. It was revealed that the frequency of occurrence of the S-allele of the 5-HTT gene in the Yakuts was significantly higher (73%), than that in the Russians (39%). In EEG, the emotional sentences induced the higher amplitude of theta-band synchronization in comparison with the neutral sentences in all participants. The participants with the genotypes LS and SS showed essentially smaller differences in amplitude of EEG reaction after onset of sentences from different categories in comparison with the people with LL genotype. Our study supports the hypothesis that S-allele of 5-HTTLPR is associated with lower sensitivity to emotion-related stimuli, that could be connected with the risk of affective pathologies in people with such allele.

Translated title of the contributionAllelic polymorphism of the serotonin transporter as a formation factor of the behavioral cognitive control in the Yakuts
Original languageRussian
Pages (from-to)21-24
Number of pages4
JournalYakut medical journal
Issue number3
Publication statusPublished - 2017

Keywords

  • serotonin transporter (5-HTT)
  • recognition of emotions
  • language comprehension
  • EEG
  • inter-ethnical comparison
  • STOP-SIGNAL PARADIGM
  • INHIBITION
  • MODEL

OECD FOS+WOS

  • 3.01 BASIC MEDICAL RESEARCH
  • 3.02 CLINICAL MEDICINE

State classification of scientific and technological information

  • 34.39 Physiology of humans and animals

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